Prostaglandin Inhibitors in Tumor Immunology and ImmunotherapyCRC Press, 28 mar 1994 - 256 páginas This book provides an updated overview of eicosanoid metabolism. It also presents a timely discussion of eicosanoid metabolism in the process of tumor cell metastasis, in chemoprotection and radioprotection associated with cancer therapy, and in cell differentiation. The book focuses on the role of eicosanoids in the immunology of malignant disease. This includes how various immune cell populations in cancer are affected by the secretion and action of various eicosanoids and metabolites of eicosanoids and how these processes may be affected by various pharmacological manipulations and interventions to augment anti-tumor immunity. Head and neck cancer is covered in great detail to illustrate a cancer in humans where these considerations are particularly relevant. This important volume demonstrates that the principal factor in cancer patient immunologic deficiency is related to excess secretion by monocytes of prostaglandins. |
Índice
Chapter | 2 |
Acknowledgments | 24 |
Participation of Lipoxygenase Products in Lymphohematopoietic | 41 |
Chapter 3 | 55 |
Eicosanoids and Tumor Cell Metastasis | 73 |
Chapter 4 | 109 |
Chapter 5 | 129 |
Chapter 6 | 171 |
Wayne R Hanson 473 Medical Sciences University of Western Ontario | 173 |
Jules E Harris Michigan State University | 181 |
Chapter 7 | 187 |
Términos y frases comunes
Acad allbẞ3 antibody antigen arachidonic acid Biochem Biol Biophys biosynthesis blastogenic responses Cancer Metastasis cancer patients Cancer Res cell adhesion cell lines cellular Chem Clin clinical clones COOH cyclooxygenase cytokines cytotoxic differentiation disease effects eicosanoids endoperoxide endothelial cells enzyme ETYA expression factor fatty acids formation gene growth head and neck Honn human immune Immunol increased indomethacin induced inhibition inhibitors integrin interleukin-1 killer cell Leuk leukocytes leukotriene Lipids lipoxins lipoxygenase lipoxygenase products lung lymphocytes macrophages malignant mechanism mediated melanoma membrane metabolism metabolites metastasis metastatic misoprostol modulation molecular molecules monocytes murine Natl natural killer NDGA neck cancer NK cells pathway peripheral blood PGE2 phospholipase platelet platelet aggregation Proc prostacyclin Prostagl prostaglandin E2 prostaglandin endoperoxide prostaglandin synthesis prostanoids protection protein radiation receptor regulation role Samuelsson SCCHN specific stimulated studies suppressor synthase TCIPA thromboxane tissues tumor cell adhesion tumor cell-platelet vitro vivo
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