DNA Repair, Genetic Instability, and Cancer
This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention.
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Chapter 1 DNA Damage Sensing and Signaling Jamie L Wood and Junjie Chen
Chapter 2 Base Excision Repair Bo Hang
Chapter 3 Nucleotide Excision Repair Lei Li
Biological Functions and Molecular Mechanisms GuoMin Li
Chapter 5 Mammalian Homologous Recombination Repair and Cancer Intervention Zhiyuan Shen and Jac A Nickoloff
Chapter 6 Role of NonHomologous End Joining in the Repair of DNA DoubleStrand Breaks Sandeep Burma Benjamin Chen and David J Chen
Chapter 7 A DNAdamage Response Network of Fanconi Anemia and BRCA Proteins Rong Guo and Weidong Wang
Lesion Recognition Wei Yang
Chapter 9 DNA Damage Tolerance and Translesion Synthesis Fang Xu Yingnian Yu and Wei Xiao
Flap Endonuclease1 as a Paradigm Purnima Singh and Binghui Shen
Application in Cancer Research Maxwell P Lee
Chapter 12 Molecular Epidemiology of DNA Repair and Cancer Susceptibility A Review of PopulationBased Studies Zhibin Hu LiE Wang and Qing...
Acad Sci USA activity adducts allelic AP endonuclease APE1 apoptosis associated base excision repair base pairs binding biochemical Biol Chem BRCA1 BRCA2 cell cycle cell cycle checkpoint cellular checkpoint Chk2 Chkl chromatin chromosome coli defective DNA damage DNA damage response DNA glycosylases DNA lesions DNA polymerase DNA repair DNA-PKcs domain double-strand break DSBs enzymes eukaryotic FANCD2 FANCJ FANCM Fanconi anemia ﬁrst ﬂap ﬂexibility function gene expression genetic genomic stability helicase hMLHl HNPCC homologous recombination human identiﬁed instability interactions involved kinase ligase mechanism mice mismatch repair Mol Cell Biol molecular monoubiquitination Mutat Res MutS Natl Acad Sci NHEJ nuclear nucleotide excision repair PCNA phenotype phosphorylation polymorphisms Proc Natl Acad regulation repair genes repair pathways repair proteins replication forks response to DNA role sequence single-stranded SNPs speciﬁcity strand structure studies substrate syndrome synthesis template tion Tolerant Benign tumor ubiquitin uracil vitro XRCC1 yeast