Genetic Recombination in CancerElsevier, 24 jul 2003 - 264 páginas Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells* Examines the role of genetic recombination in cancer including cancer invasion and metastasis* Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers |
Índice
1 | |
3 | |
Chapter 3 Replication error RER and genetic instability | 24 |
Chapter 4 DNA repeats genetic recombination and the pathogenesis of genetic disorders | 41 |
Chapter 5 Chromosomal recombination in cancer | 67 |
Chapter 6 Chromosomal translocation and its phenotypic effects | 76 |
Chapter 7 DNA methylation and genetic instability | 133 |
Chapter 8 Telomeric DNA and genetic instability | 154 |
Epilogue | 164 |
References | 170 |
237 | |
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Términos y frases comunes
aberrant abnormalities Acad Sci USA activation allelic Alu repeats aneuploidy apoptosis apoptotic associated binding Biol Chem BRCA1 breakpoints breast cancer CAG repeat cancer cells Cancer Res carcinoma cell cycle cell lines cell proliferation cellular chimeric chromatid chromosomal translocation colorectal correlation CpG islands deletion deregulation differentiation disease DNA damage DNA methylation DNA ploidy DNA-PK domain elements exon expression FHIT FMR1 fragile function fusion protein genetic instability genetic recombination genomic growth factor HDAC hMLH1 homologue human hypermethylation inactivation induced inhibit inhibitors interaction intron invasive involved kinase Ku protein leukaemia locus loss lymphoma mediated metastasis metastatic microsatellite instability mismatch repair genes Mol Cell mutations Natl Acad Sci neoplastic notch signalling occur Oncogene over-expression pathogenesis pathway patients phenotype phosphorylation ploidy Proc Natl Acad receptor regulation replication RER+ SEL1L sequences Sherbet Sherbet GV suppressor genes syndrome T-cell TCL1 telomerase telomere transcription factor transfected tumour cells tumour suppressor