Application of Apoptosis to Cancer Treatment

Portada
Mels Sluyser
Springer Science & Business Media, 14 abr 2005 - 370 páginas

Novel drugs are being developed which interact with the programmed cell death (apoptotic) machinery in cancer cells, thereby causing these cells to commit suicide and to be removed from the body. Research is also directed to investigate why the cancer cells sometimes lose the ability to undergo apoptosis after a certain period of time and methods are being developed to reactivate this cell death process. This book is intended for workers in the field and clinicians as a useful guide of the state of affairs in this exciting field which may offer more effective possibilities for treatment of cancer patients.

Mels Sluyser is the Editor of the journals APOPTOSIS and ANTI-CANCER DRUGS. He brings together a collection of papers written by the world’s leading experts in these fields.

 

Páginas seleccionadas

Índice

Disfunctions of the Apoptotic Pathway in Cancer Cells
1
Calcium Signaling and Apoptosis Resistance of Cancer Cells
29
Cell Clearance and Cancer
51
Specific ProPoptotic CellSignaling Design of Novel Recombinant Targeted Antitumor Agents Operating Exclusively Through Modulation of Cellular...
85
Targeting Oncogenes which Regulate Apoptosis
117
Targeting Cyclins to Cause Cancer Cell Apoptosis
145
Apoptosis Induction by TumorTargeted Toxins
179
Targeting CellDeath pathways in Multiple Myeloma Therapeutic Implications
189
Hamlet a Novel Tool to Identify Apoptotic Pathways in Tumor Cells
223
Cancer Immunotherapy On the Trail of a Cure?
247
Histone Deacetylase Inhibitors as a Treatment of TrailResistant Cancers
271
Basis of Cell Kill Following Clinical Radiotherapy
293
Imaging of Apoptotic Cells in Vivo
321
ApoptosisInducing Anticancer Drugs in Clinical Trials
341
Index
365
Página de créditos

Cephalostatin 1Induced Apoptosis in Tumor Cells Selective Induction of SmacDIABLO Release
209

Otras ediciones - Ver todo

Application of Apoptosis to Cancer Treatment
Mels Sluyser
Vista previa restringida - 2005
Application of Apoptosis to Cancer Treatment
Mels Sluyser
No hay ninguna vista previa disponible - 2010

Términos y frases comunes

agents anti-apoptotic antibody anticancer apoptosis-inducing apoptosome apoptotic cells apoptotic pathway apoptotic signaling Bcl-2 family Bcl2 binding Biol Chem Bortezomib breast cancer Ca2+ cancer cells Cancer Res carcinoma caspase activation caspase-3 caspase-9 CDK2 Cell Biol cell cycle cell lines cellular cephalostatin chemotherapeutic chemotherapy chromatin clearance cleavage clinical Cyclin Cyclin E cytochrome cytoplasm cytotoxic death receptors DNA damage drug effects expression Fas ligand function gene granzyme GrB/scFvMEL HAMLET HDIs histone deacetylase human tumor Immunol induces apoptosis inhibition interaction intracellular kinase leukemia ligand macrophages malignant mechanisms mediated melanoma membrane mice mitochondrial Mitsiades molecular molecules multiple myeloma mutations NF-kB normal cells novel nuclear Oncogene Oncol overexpression patients phagocytosis phosphatidylserine phosphorylation pro-apoptotic proliferation prostate cancer protease proteasome protein radiation radiotherapy regulation release resistance response role sensitivity signaling pathways Smac/DIABLO studies survival survivin target therapeutic therapy tissue toxin transcription treatment trigger tumor cells tumor necrosis upregulation vitro vivo XIAP

Pasajes populares

Página 359 - JC (1998) lAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. Embo J 77,2215-2223.‎
Aparece en 68 libros entre 1999 y 2008
Página 359 - Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, SM, Ahmad, M., Alnemri, ES, and Wang, X., 1997, Cytochrome c and dATP-dependent formation of Apaf-l/caspase-9 complex initiates an apoptotic protease cascade, Cell 91: 479.‎
Aparece en 109 libros entre 1992 y 2008

Información bibliográfica

TítuloApplication of Apoptosis to Cancer Treatment
EditorMels Sluyser
Ediciónilustrada
EditorSpringer Science & Business Media, 2005
ISBN1402033036, 9781402033032
N.º de páginas370 páginas
  
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