Chemical Biology of Neurodegeneration: A Molecular Approach

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John Wiley & Sons, 19 nov. 2019 - 384 páginas
Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders

Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient.

Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents.

-Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain
-Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs
-Covers six key neurotransmitter systems and their enzymes and receptors?dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic

Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and neurophysiologists.
 

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Índice

Preface
1
5
29
The Noradrenergic System
41
The Serotonergic System
81
The Cholinergic System
121
The Glutamatergic System
155
The GABAergic System
199
Metabolism and Proteins
227
Enzymes Processing Neurotransmitters
249
6
274
Misfolded Proteins
303
Therapeutic Agents for Neurodegenerative Disorders
325
7
333
Index
359
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Sobre el autor (2019)

Pedro Merino, PhD, holds the Chair in Organic Chemistry at the University of Zaragoza, Spain. His scientific work has been presented in more than 220 papers, various book chapters, and one book. His research interests include chemical biology with particular focus on glycoscience, computational chemistry, asymmetric synthesis and catalysis.

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