The Search for New Anticancer DrugsMichael Waring, B.A. Ponder Springer Science & Business Media, 30 nov 1992 - 296 páginas Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science. This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells. The genome, then (DNA in biochemical terms), surely represents a critical target for specific chemotherapy of cancer, and several chapters address the issue of attacking DNA, gene targetting, and the like. Others deal with principles of rational design, exploitation of novel modalities and targets, or the nuts and bolts of antitumour drug testing. While no attempt has been made to provide a comprehensive coverage of this wide-ranging and vitally important subject, the present volume in the series will provide much food for thought. |
Índice
Is there a future for the small molecule in developmental cancer chemotherapy? | 1 |
The role of medicinal chemistry in the discovery of DNAactive anticancer drugs from random searching through lead development to de novo design | 19 |
In vitro systems for anticancer drug testing | 55 |
Tumour hypoxia challenges for cancer chemotherapy | 87 |
Computer modelling and drug design | 133 |
Differentiation inducers and their potential use in the treatment of acute myelogenous leukaemia | 163 |
Angiosuppression | 183 |
Preclinical evaluation and phase I trials | 229 |
Evaluation how should a new treatment be evaluated? | 245 |
Oncogenetargeted antisense oligonucleotides tools for genetic analysis or new anticancer drugs? | 259 |
| 279 | |
Otras ediciones - Ver todo
The Search for New Anticancer Drugs Michael Waring,B.A. Ponder No hay ninguna vista previa disponible - 2011 |
The Search for New Anticancer Drugs Michael Waring,B.A. Ponder No hay ninguna vista previa disponible - 2011 |
Términos y frases comunes
Acad agents alkylating amsacrine analogues angiogenesis angiogenic angiosuppressive anti-sense antibodies anticancer drugs antitumour activity Baguley binding Biochem Biol biological bioreductive blood c-myc Cancer Inst Cancer Res carcinoma cell lines Chem chemosensitivity chemotherapy Clin clinical trial clonogenic assays complex compounds cytotoxic cytotoxins Denny differentiation dose doxorubicin drug design effect endothelial cells enzyme expression Folkman gene growth factor HSCs human tumour hypoxia hypoxia-selective hypoxic hypoxic cells induced inhibition inhibitors interactions intercalation interferon leukaemia leukaemia cells leukaemic mechanism melanoma membrane metabolism metastasis mice misonidazole molecules mouse mRNA murine myeloid Natl nitracrine nitroimidazoles nitroreductase normal Nucleic Acids oligodeoxynucleotides oligonucleotides oncogene Oncol oxygen patients Pharmacol phase potential Proc promyelocytic protein Radiat radiosensitizers receptor reduction resistance response retinoic acid retinoids selectivity sensitivity sequence solid tumours structure studies suramin synthesis synthetic target testing therapeutic therapy tissue TNFa toxicity treatment tumor necrosis factor tumour tumour cells vascular vitro vivo xenografts