Hormones and Cancer
The series, Hormones in Health and Disease, was launched in 1993 to provide a scientific platform for investigators engaged in research on the biological actions of hormones and to anticipate relevance for their findings in clinical applications. The first volume of the series was dedicated to the discussion and understanding of molecular mechanisms by which steroid hormones influence target cells in normal and pathological conditions. With the diversity of information and the vast amount of literature on steroid hormone physiology, a more thorough treatment of Hormones and Cancer was identified as a timely topic. In this second volume in the series, Dr. Wayne V. Vedeckis has success fully undertaken the monumental task of editing the findings of the leading investigators in hormone and cancer research. Dr. Vedeckis brings to this project two decades of research experience in hormone action; he is actively engaged in elucidating hormone and cancer interrelations. It is a pleasure to welcome him to the series as an editor and congratulate him and all contribu tors in presenting this comprehensive treatise. The 20 chapters include discussions on contemporary topics relating control of cell division and signal transduction to the basic mechanisms of carcinogenesis by cloning patient genes, and recognizing the importance of steroid receptors in treatment protocols of various endocrine abnormalities.
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RET ProtoOncogene and Its Role in Multiple Endocrine
Concepts for Separation of Desirable
The Genetics of Breast Cancer
Growth Factors and Modulation of Endocrine Response
Role of Altered Estrogen Receptors in Breast Cancer
Tumor Suppressor Genes and Oncogenes in Human Prostate
Prostatic Growth Factors Cancer and Steroid Hormone
Glucocorticoid Actions on Normal and Neoplastic
Clinical Aspects of Acute Promyelocytic Leukemia
Molecular Biology of Acute Promyelocytic Leukemia
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Acad Sci USA adjuvant allele androgen receptor antiestrogen apoptosis aromatase ATRA Biochem Biol Chem BRCA1 breast cancer breast cancer cells cancer cell lines Cancer Res carcinoma cell cycle cell proliferation cellular chemotherapy chromosome Clin clinical complex cyclin D1 differentiation dimerization disease DNA binding effects endocrine epithelial cells estradiol estrogen receptor expression function genetic glucocorticoid receptor heterodimers hormone receptor human breast cancer human prostate cancer IGF-I induced inhibition inhibitors interaction kinase leukemia levels ligand malignant mammary mechanism mediated metastatic Mol Endocrinol molecular mRNA mutations Natl Acad Sci normal nuclear receptors oncogene overexpression pathways phenotype phosphorylation PML/RARO Proc Natl Acad progesterone prostate cancer prostate cancer cell prostate tumors protein RARO region regulation response elements retinoblastoma retinoic acid receptor retinoid risk role sequences specific studies tamoxifen TGF-o therapy tissue transactivation transcription factor transcriptional activity treatment Tsai tumor suppressor tumor suppressor gene vitamin vitro