Cancer Immunology: Innovative Approaches to Therapy, Volumen 27;Volumen 1986Ronald B. Herberman Springer Science & Business Media, 28 feb 1986 - 229 páginas This volume is the second in the 'Cancer Treatment and Research' series focussing on basic and clinical tumor immunology. It has a rather different focus or emphasis from that of the first volume, published two years ago. That work (Basic and Clinical Tumor Immunology, R.B. Herberman, ed., Martinus Nijhoff Publishers, 1983) devoted considerable attention to up dated summaries in various areas of classical tumor immunology: specific antitumor immunity, the immunologic competence of cancer patietns, char acterization of human tumor-associated antigens, the ability to propagate specifically immune T cells in culture in the presence of interleukin 2, and the use of such cells for adoptive immunotherapy of established tumors. of evidence concerning the immune However, it also reviewed the status surveillance hypothesis and pointed out the need to consider non-T cell mediated mechanisms of host resistance. In particular, one chapter sum marized information on the role of macrophages in host resistance against tumors. The present volume continues to emphasize one of the major themes of the first volume, innovative approaches to the therapy of cancer. It involves contributions from leading investigators on several primary types of therapeutic interventions related to monoclonal antibodies, the col laboration of monoclonal antibodies with macro phages to mediate antibody dependent cellular cytotoxicity, lymphokines, tumor vaccines, and natural killer cells. It also has an up-to-date summary of the immunologic aspects of the exciting and promising work being performed on human T cell leukemia virus in the laboratory of Dr. Robert Gallo. |
Índice
1 | |
implications for the immunobiology of neoplasia | 29 |
mechanisms of recognition and lysis and their regulation | 69 |
4 Mechanism of NKcell mediated cytotoxicity | 123 |
5 Role of natural killer NK cells in the control of tumor growth and metastatic spread | 151 |
preclinical models and investigations in humans | 177 |
7 Abnormalities in interleukin 2 production and response in cancer and possible therapeutic approaches | 201 |
221 | |
Otras ediciones - Ver todo
Cancer Immunology: Innovative Approaches to Therapy Ronald B. Herberman Vista previa restringida - 2012 |
Cancer Immunology: Innovative Approaches to Therapy Ronald B. Herberman No hay ninguna vista previa disponible - 2012 |
Cancer Immunology: Innovative Approaches to Therapy Ronald B Herberman No hay ninguna vista previa disponible - 1986 |
Términos y frases comunes
5-azacytidine Acad activated macrophages ADCC anti antibody-dependent antigens antimetastatic effect assay binding blood Cancer Res cell lines cell surface cell-cell cell-mediated cellular clones conjugates cytolysis cytolytic cytotoxicity drug DTIC effector cells Fc receptors function Gallo gene granules growth factor Herberman HTLV HTLV-I HTLV-III human monocytes human natural killer human T-cell IL2 production IL2 receptor immune immunogenic immunogenic variants Immunol Immunology induced infection inhibition interaction interferon Interleukin killing lymphocytes lymphokine lymphoma lysis lytic lytic process macrophage activation macrophage-mediated macrophages malignant mechanism mediated melanoma membrane metastatic MHC expression mice molecular molecules monoclonal antibody monocytes mouse murine mutagenic Natl natural killer cells NK activity NK cell activity NK cells NK reactivity NKCF patients phages phenotype Proc protease protein response Robert-Guroff role secretion selective serum slow ADCC specific spontaneous stimulation studies syngeneic T-cell leukemia target cells therapy tion toxicity toxin treatment tumor cells viral vitro vivo