Molecular Aspects of Cancer and Its Therapy
This book highlights recent progress in the molecular, cellular and immunological mechanisms that contribute to the pathophysiology of cancer and the design of therapeutic modalities based upon these molecular insights. Areas of particular emphasis include cancer immunology and the immunotherapy of cancer, the role of cytokines in modulating the social bahaviour of cancer cells, the genetic alterations that characterize human cancer and metastasis, and a consideration of the more experimental approaches to cancer therapy, including gene therapy using expression vectors for cytokines and their receptors, antisense RNA therapy, and anti-idiotypic antibody immunization. This volume serves to introduce the general reader as well as the cancer specialist to personalized perspectives of particular topics in cancer research by leading research groups in the field. The combination of a ''reviews''-approach with a more research-oriented approach in discussions of specific research topics provides a stimulating and, hopefully, forward-looking volume which serves to update selected aspects of cancer research today. This combination will be useful to both the beginner as well as the more advanced biomedical scientist.
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Genetic control of metastasis
Cytokines in breast cancer cell dyshesion
Clinical relevance of genetic alterations in lung cancer
Recent advances in understanding function and mutations of breast cancer susceptibility genes
Cytokines in the hosttumor interaction
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Acad Sci USA activity adenovirus aFGF alterations antibody antigen antisense apoptosis AS-ODNs autologous bcr/abl Biochem Biol biological biomarkers bladder cancer BRCA1 BRCA2 breast cancer breast carcinoma c-myb c-myc cancer cells carcinogenesis carcinoma cells cDNA cell lines cellular chromosome clinical clones complex cultures cytokines detected disease effect epigenetic Ex vivo function gene expression gene therapy gene transfer genetic instability genome growth factor HSV-TK human Immunol immunotherapy induced inhibition injection interaction interleukin-6 kinase leukemia lung cancer lymphocytes malignant markers mechanisms melanoma melanoma cells metastasis metastatic metastatic phenotype metastatic potential mice molecular molecules mouse mRNA murine mutations Natl Acad Sci NDPK ng/ml normal oncogene ovarian cancer patients phenotype Proc Natl Acad proliferation prostate cancer protein receptor recombinant regulation Retrovirus ribozymes risk sequence signaling pathways specific studies therapeutic gene tissue transcription transduction transfected treatment tumor tumor heterogeneity tumor suppressor gene tumorigenic tumour cells tumour suppressor vaccine vectors viral