Pulmonary Immunotoxicology

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Mitchell D. Cohen, Judith T. Zelikoff, Richard B. Schlesinger
Springer Science & Business Media, 30 jun. 2000 - 465 páginas
Pulmonary Immunotoxicology is a comprehensive exploration of the effects of various inhaled materials upon the immune system of the respiratory tract. It will be useful to investigators in the field of pulmonary toxicology and immunotoxicology, and to those involved in administration and regulation of matters related to inhaled materials. It can also serve as a textbook for a course in pulmonary immunotoxicology at graduate or advanced undergraduate level.
Pulmonary Immunotoxicology comprises four sections. The first provides basic background concepts essential for understanding pulmonary immunotoxicology, including discussions of the normal structure and function of the respiratory system, its basic immunology, and the manner by which inhaled particles and gases are removed from the air and deposited upon respiratory tract surfaces. The second section provides an overview of the major types of pathological consequences which can arise from immunomodulation within the respiratory tract, including hypersensitivity and asthma, inflammation and fibrosis, as well as immunosuppression and autoimmunity. The third section, which comprises the largest portion of the book, deals specifically with major classes of airborne agents that are known to alter the immune function of the respiratory tract. These are arranged into major classes: organic agents, metals, gases, particles, biologics, and complex mixtures. The fourth and final section of the book explores the area of risk assessment, including discussions of the basic concepts of risk assessment as they apply specifically to immunotoxicologic effects upon the lungs, and the use of biomarkers as indices of potential pulmonary immunotoxic responses to inhaled materials.
 

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Índice

AIRWAY ARCHITECTURE IN HUMANS AND ANIMALS
1
2 IMMUNOLOGY OF THE RESPIRATORY TRACT
61
3 DISPOSITION OF INHALED PARTICLES AND GASES
85
4 HYPERSENSITIVITY AND ASTHMA
107
5 INFLAMMATION AND FIBROSIS
127
6 PULMONARY AUTOIMMUNITY AND INFLAMMATION
153
7 BIOLOGICAL AGENTS
181
8 PESTICIDES SOLVENTS AND POLYCYCLIC AGENTS
199
ALUMINUM COPPER MANGANESE SELENIUM VANADIUM AND ZINC
265
12 OZONE
299
13 SULFUR AND NITROGEN OXIDES
335
14 ASBESTOS AND SILICA
351
15 WOODSMOKE KEROSENE HEATER EMISSIONS AND DIESEL EXHAUST
367
16 TOBACCO SMOKE
385
17 APPLYING PULMONARY IMMUNOTOXICITY DATA TO RISK ASSESSMENT
409
18 BIOMARKERS OF PULMONARY IMMUNOLOGIC RESPONSES
431

9 BERYLLIUM
213
10 ARSENIC CADMIUM CHROMIUM AND NICKEL
241

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Página 430 - US Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the US Environmental Protection Agency; nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

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