Pulmonary ImmunotoxicologyMitchell D. Cohen, Judith T. Zelikoff, Richard B. Schlesinger Springer Science & Business Media, 30 jun 2000 - 465 páginas Pulmonary Immunotoxicology is a comprehensive exploration of the effects of various inhaled materials upon the immune system of the respiratory tract. It will be useful to investigators in the field of pulmonary toxicology and immunotoxicology, and to those involved in administration and regulation of matters related to inhaled materials. It can also serve as a textbook for a course in pulmonary immunotoxicology at graduate or advanced undergraduate level. Pulmonary Immunotoxicology comprises four sections. The first provides basic background concepts essential for understanding pulmonary immunotoxicology, including discussions of the normal structure and function of the respiratory system, its basic immunology, and the manner by which inhaled particles and gases are removed from the air and deposited upon respiratory tract surfaces. The second section provides an overview of the major types of pathological consequences which can arise from immunomodulation within the respiratory tract, including hypersensitivity and asthma, inflammation and fibrosis, as well as immunosuppression and autoimmunity. The third section, which comprises the largest portion of the book, deals specifically with major classes of airborne agents that are known to alter the immune function of the respiratory tract. These are arranged into major classes: organic agents, metals, gases, particles, biologics, and complex mixtures. The fourth and final section of the book explores the area of risk assessment, including discussions of the basic concepts of risk assessment as they apply specifically to immunotoxicologic effects upon the lungs, and the use of biomarkers as indices of potential pulmonary immunotoxic responses to inhaled materials. |
Índice
AIRWAY ARCHITECTURE IN HUMANS AND ANIMALS | 1 |
2 IMMUNOLOGY OF THE RESPIRATORY TRACT | 61 |
3 DISPOSITION OF INHALED PARTICLES AND GASES | 85 |
4 HYPERSENSITIVITY AND ASTHMA | 107 |
5 INFLAMMATION AND FIBROSIS | 127 |
6 PULMONARY AUTOIMMUNITY AND INFLAMMATION | 153 |
7 BIOLOGICAL AGENTS | 181 |
8 PESTICIDES SOLVENTS AND POLYCYCLIC AGENTS | 199 |
ALUMINUM COPPER MANGANESE SELENIUM VANADIUM AND ZINC | 265 |
12 OZONE | 299 |
13 SULFUR AND NITROGEN OXIDES | 335 |
14 ASBESTOS AND SILICA | 351 |
15 WOODSMOKE KEROSENE HEATER EMISSIONS AND DIESEL EXHAUST | 367 |
16 TOBACCO SMOKE | 385 |
17 APPLYING PULMONARY IMMUNOTOXICITY DATA TO RISK ASSESSMENT | 409 |
18 BIOMARKERS OF PULMONARY IMMUNOLOGIC RESPONSES | 431 |
Otras ediciones - Ver todo
Pulmonary Immunotoxicology Mitchell D. Cohen,Judith T. Zelikoff,Richard B. Schlesinger Vista previa restringida - 2012 |
Pulmonary Immunotoxicology Mitchell D Cohen,Judith T Zelikoff,Richard B Schlesinger No hay ninguna vista previa disponible - 2000 |
Pulmonary Immunotoxicology Mitchell D. Cohen,Judith T. Zelikoff,Richard B. Schlesinger No hay ninguna vista previa disponible - 2012 |
Términos y frases comunes
acid activity acute adhesion aerosol air pollutants airway allergen allergic alveolar macrophages animals antibody antigen Appl asbestos associated asthma bacterial beryllium Biol bronchial cellular chemical chemokines chronic Clara cells clearance Clin collagen compounds concentrations cytokines decreased dendritic cells deposition effects endothelial cells enhanced Environ Environmental enzymes eosinophils epithelial cells epithelium exposed factor fibers fibroblasts fibronectin function guinea pigs Health host human hypersensitivity immune response immune system Immunol immunologic immunotoxicity increased induced infection inflammation inflammatory response inhaled inhibition Interleukin interstitial lavage leukocytes levels lymphocytes macrophages mast cells mechanisms mediators metal mice molecules monocytes nasal neutrophils nitrogen dioxide O3 exposure occupational oxide ozone particles phagocytic phagocytosis Pharmacol ppm O3 production proliferation proteins pulmonary fibrosis rabbits rats reactions receptor release Respir respiratory tract role Selgrade sensitization serum soluble species stimulation studies suppression surface T-lymphocyte tobacco smoke toxicity Toxicol Toxicology tumor vitro vivo Wegener's granulomatosis
Pasajes populares
Página 430 - US Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the US Environmental Protection Agency; nor does mention of trade names or commercial products constitute endorsement or recommendation for use.
Referencias a este libro
Inhalation Studies: Foundations and Techniques Robert F. Phalen No hay ninguna vista previa disponible - 2008 |