The Molecular and Cellular Biology of Wound Repair

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Springer Science & Business Media, 6 dic 2012 - 597 páginas
Editing a book of this nature was a simultaneously exhilarating and frightening experience. It was exhilarating to draw from cell biologists, biochemists, and molecular biologists, as well as those dermatologists, pathologists, and pul monologists who are cell biologists at heart, to author chapters. At the same time, it was frightening to ask such busy investigators to devote their precious time to writing chapters that summarize not just their own endeavors but their entire area of expertise. However, the authors assuaged our fears by enthusi astically accepting the proposal to write on specific topics despite the time burden, and to update and willingly accept our editorial comments. In the editors' view, the authors have captured the important scientific data in their respective fields, have organized the data into an understandable outline, and have applied the information to elucidating wound repair processes. The explosion of new, important discoveries in the field of wound repair and related areas as our book was developing has been very unsettling. This observation predicts obsolescence. In response to this possibility, the authors and the editors have attempted to build fundamental concepts upon existing data. Hopefully, these concepts will help provoke further experimentation to unravel the complex, interwoven processes of wound repair. The book has been organized into three parts: Inflammation, Granulation Tissue Formation, and Extracellular Matrix Production and Remodeling.
 

Índice

Chapter 1
3
Chapter
6
Granulation Tissue
9
Chapter
15
Matrix Formation and Remodeling
16
Chapter
19
Chapter 2
35
Chapter 3
39
Chapter 14
321
Metabolic Requirements and Epithelial Migration
328
Joseph A Madri and Bruce M Pratt
337
Chapter 4
352
Chapter 16
359
Endothelial Cell Growth Inhibitory Proteins
365
Chapter 17
373
48
399

Potential Functions of the Clotting System in Wound Repair
57
Chapter 5
115
Leukocyte Chemoattractants
126
Conclusion
137
Neutrophil Emigration Activation and Tissue Damage
149
Migration of Neutrophils through Vascular Endothelium
157
Phagocytic Killing of Microorganisms by Neutrophils
165
Conclusion
175
Chapter 7
185
Summary
205
References
207
Origin and Kinetics of Macrophages
214
Monocyte Maturation and Differentiation
221
Macrophage Involvement in Tissue Remodeling
228
Chapter 9
243
Chapter 10
253
Chapter 11
265
Chapter 12
273
Chapter 13
281
Molecular Basis of CellSubstratum Adhesion
291
Migration of Specific Cell Populations into Wounds
299
Concluding Remarks
308
Chapter 18
405
The Role of Fibronectin in Matrix Assembly
416
Regulation of Fibronectin Synthesis
425
Proteoglycans and Wound Repair
437
Effects of Proteoglycans on Cellular Behavior in Wound Repair
448
Conclusions
461
57
469
Chapter 20
471
Collagen Synthesis and Deposition in Normal Wound Repair
477
CollagenBased Biomaterials in the Treatment of Dermal Wounds
490
58
495
Chapter 21
497
Collagenases
505
Hyaluronidase
513
Chapter 22
525
Macromolecular Organization of Basement Membranes
542
The Basement Membrane in Wound Repair
550
Chapter 23
559
Index
587
59
588
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