The Molecular and Cellular Biology of Wound RepairSpringer Science & Business Media, 6 dic 2012 - 597 páginas Editing a book of this nature was a simultaneously exhilarating and frightening experience. It was exhilarating to draw from cell biologists, biochemists, and molecular biologists, as well as those dermatologists, pathologists, and pul monologists who are cell biologists at heart, to author chapters. At the same time, it was frightening to ask such busy investigators to devote their precious time to writing chapters that summarize not just their own endeavors but their entire area of expertise. However, the authors assuaged our fears by enthusi astically accepting the proposal to write on specific topics despite the time burden, and to update and willingly accept our editorial comments. In the editors' view, the authors have captured the important scientific data in their respective fields, have organized the data into an understandable outline, and have applied the information to elucidating wound repair processes. The explosion of new, important discoveries in the field of wound repair and related areas as our book was developing has been very unsettling. This observation predicts obsolescence. In response to this possibility, the authors and the editors have attempted to build fundamental concepts upon existing data. Hopefully, these concepts will help provoke further experimentation to unravel the complex, interwoven processes of wound repair. The book has been organized into three parts: Inflammation, Granulation Tissue Formation, and Extracellular Matrix Production and Remodeling. |
Índice
3 | |
6 | |
9 | |
Chapter | 15 |
Matrix Formation and Remodeling | 16 |
Chapter | 19 |
Chapter 2 | 35 |
Chapter 3 | 39 |
Chapter 14 | 321 |
Metabolic Requirements and Epithelial Migration | 328 |
Joseph A Madri and Bruce M Pratt | 337 |
Chapter 4 | 352 |
Chapter 16 | 359 |
Endothelial Cell Growth Inhibitory Proteins | 365 |
Chapter 17 | 373 |
48 | 399 |
Potential Functions of the Clotting System in Wound Repair | 57 |
Chapter 5 | 115 |
Leukocyte Chemoattractants | 126 |
Conclusion | 137 |
Neutrophil Emigration Activation and Tissue Damage | 149 |
Migration of Neutrophils through Vascular Endothelium | 157 |
Phagocytic Killing of Microorganisms by Neutrophils | 165 |
Conclusion | 175 |
Chapter 7 | 185 |
Summary | 205 |
References | 207 |
Origin and Kinetics of Macrophages | 214 |
Monocyte Maturation and Differentiation | 221 |
Macrophage Involvement in Tissue Remodeling | 228 |
Chapter 9 | 243 |
Chapter 10 | 253 |
Chapter 11 | 265 |
Chapter 12 | 273 |
Chapter 13 | 281 |
Molecular Basis of CellSubstratum Adhesion | 291 |
Migration of Specific Cell Populations into Wounds | 299 |
Concluding Remarks | 308 |
Chapter 18 | 405 |
The Role of Fibronectin in Matrix Assembly | 416 |
Regulation of Fibronectin Synthesis | 425 |
Proteoglycans and Wound Repair | 437 |
Effects of Proteoglycans on Cellular Behavior in Wound Repair | 448 |
Conclusions | 461 |
57 | 469 |
Chapter 20 | 471 |
Collagen Synthesis and Deposition in Normal Wound Repair | 477 |
CollagenBased Biomaterials in the Treatment of Dermal Wounds | 490 |
495 | |
Chapter 21 | 497 |
Collagenases | 505 |
Hyaluronidase | 513 |
Chapter 22 | 525 |
Macromolecular Organization of Basement Membranes | 542 |
The Basement Membrane in Wound Repair | 550 |
Chapter 23 | 559 |
587 | |
588 | |
Otras ediciones - Ver todo
The Molecular and Cellular Biology of Wound Repair Richard A. F. Clark,Peter M. Henson Vista de fragmentos - 1988 |
Términos y frases comunes
Acad acid adhesion angiogenesis antibodies antigen basement membrane binding Biochem bovine bradykinin capillary Cell Biol cell migration cell surface cellular Chapter Chem chemoattractant chemotactic factors chemotaxis Clin clot coagulation collagenase complex components connective tissue cultured degradation effect endo endothelial cells endothelium enzymes epidermal growth factor epithelial cells extracellular matrix factor Xa fibrin fibrinogen fibroblasts fibronectin formation fragments function glycoprotein glycosaminoglycans granulation tissue Henson heparan sulfate heparin histamine human hyaluronic Immunol induced inflammation inflammatory inhibition inhibitor interaction Invest isolated lamina laminin leukocytes macrophages mechanisms mediators microvascular molecules monocytes motility myofibroblasts Natl Nature Lond neutrophil Pathol pathway PDGF peptides permeability plasma plasminogen activator platelet-derived growth factor platelets Proc procoagulant proliferation prostaglandins protease protein rabbit receptor release response role secretion sequence serum skin smooth muscle cells stimulated structure studies synthesis thrombin tion tissue factor tissue injury type IV collagen vascular vitro vivo wound healing wound repair