Rheumatic Diseases: Immunological Mechanisms and Prospects for New TherapiesJ. S. H. Gaston Cambridge University Press, 28 jul 1999 - 288 páginas This authoritative volume provides a wide-ranging account of the immunological mechanisms that underlie many rheumatic diseases. Advances in our understanding of the immunopathology of diseases such as rheumatoid arthritis, ankylosing spondylitis and SLE, are paving the way for the development of effective and rational new therapies. This exciting prospect is an important influence for ground-breaking research into these diseases and the investigation of new therapeutic options. As the first book to focus exclusively on this burgeoning area of clinical research, this is an invaluable and current resource for all rheumatologists, clinical immunologists, and those seeking to develop effective new therapies to combat rheumatic diseases. |
Índice
The role of T cells in autoimmune disease R J Moots and | 13 |
The role of MHC antigens in autoimmunity J Hoyt Buckner | 33 |
formation and structure of autoantibodies | 61 |
The role of CD40 in immune responses P Lane | 79 |
Manipulation of the T cell immune system via CD28 and | 93 |
Lymphocyte antigen receptor signal transduction | 119 |
The role of adhesion mechanisms in inflammation | 153 |
The regulation of apoptosis in the rheumatic disorders | 183 |
The role of monokines in arthritis W B van den Berg and | 203 |
T lymphocyte subsets in relation to autoimmune disease | 225 |
Complement receptors J M Ahearn and A M Rosengard | 245 |
| 277 | |
Términos y frases comunes
Acad alleles amino acid anti anti-DNA antigen antigen receptor apoptosis apoptotic Arthritis Rheum associated autoantibodies autoimmune disease autoreactive binding Biol cartilage CD4+ T cells cell activation cell clones cell surface chain Chem chemokines class II molecules Clin clonal complement receptor complement receptor type complex cytokines cytoplasmic diabetes domain encoded endothelial epitope expression factor FasL Fearon function gene genetic human immune response immune system immunoglobulin Immunol induced inflammation inflammatory inhibit integrin interaction interleukin intracellular involved L-selectin leukocyte ligand lymphocytes macrophages mechanisms mediated membrane mice molecular motif mouse murine mutations Natl Nepom neutrophils normal pathogens pathway patients peptide peripheral phosphorylation polymorphic Proc proliferation protein rats region regulation residues rheumatic diseases rheumatoid arthritis role sequence SH2 domains signal transduction soluble specific Springer structure studies subsets superantigen syndrome synovial synovium T-cell tion tissue transgenic tyrosine kinases vitro vivo