Purines: Basic and Clinical AspectsSpringer Science & Business Media, 6 dic 2012 - 257 páginas Many groups of biologically important compounds experience cycles of furious research activity and near oblivion. The purines however seem not to be falling into such a pattern. Interest seems to be continuing almost exponentially with no sign of diminution. The result is a frighteningly extensive literature and an increas ing demand for international conferences and symposia. Unfortunately meetings such as these also spawn increasingly voluminous proceedings and it becomes more and more difficult for a newcomer to the area, or a non specialist, to obtain the general introductory survey he needs. This volume therefore is not intended to be comprehensive - far from it. We have tried to be selective in the material presented and the references quoted. They should provide a quick guide and access to key works in the literature which can be expanded by library or computerised searching. We hope that our efforts will widen the appreciation of purines as biologically important substances and will herald the day when more purine related drugs than the handful currently available are used for the selective treatment of disease. We are grateful to the many authors and publishers who have given permission to reproduce figures or quote unpublished results, and to Anne Stone for her patient typing of the manuscript. |
Índice
Tissue specificity of purine metabolism | 23 |
Purine absorption and excretion | 51 |
Extracellular activities purine receptors and pharmacology | 69 |
The nervous system cellular aspects | 90 |
The central nervous system behaviour | 115 |
The cardiovascular system | 137 |
Purines and the control of renal function | 158 |
Clinical consequences of aberrant purine metabolism | 187 |
References | 216 |
245 | |
Otras ediciones - Ver todo
Purines: Basic and Clinical Aspects T.W. Stone,Anne Simmonds No hay ninguna vista previa disponible - 2012 |
Purines: Basic and Clinical Aspects T. W. Stone,Anne Simmonds No hay ninguna vista previa disponible - 1991 |
Términos y frases comunes
2-chloroadenosine A2 receptors acetylcholine action of adenosine activity adenine nucleotides adenosine deaminase adenosine receptors adenylate cyclase agonists allopurinol AMPDA analogues antagonists APCPP APPCP APRT benzodiazepine binding blood brain calcium cells cellular clinical compounds concentrations coronary cycle cyclic AMP defect degradation demonstrated dipyridamole disorders effects of adenosine endogenous enzyme erythrocyte excretion extracellular function gene gout guanine guinea-pig HGPRT hippocampus human hypoxanthine increase induced inhibition inosine intestinal involved kidney levels liver mechanism mediated membrane morphine NECA nerve stimulation neurones non-adrenergic non-cholinergic noradrenaline normal novo nucleotidase nucleotide pathways patients peripheral Pharmacol pharmacological Physiol plasma PNP deficiency potency potential PP-ribose-P presynaptic produced protein purine metabolism purine nucleotide purine receptors R-PIA reduced relaxant renal failure responses role SAHH salvage sensitivity smooth muscle specific studies synthesis theophylline tissues transmitter release uptake urate uric acid vascular vitro vivo xanthine oxidase