Meningitis is an uncommon but serious illness at any age, and during the first few weeks of life it poses a particular hazard with high mortality and a considerable risk to survivors of permanent damage to the developing brain. This book comprehensively reviews bacterial, fungal and viral forms of the illness. Epidemiology and comparisons of maternally and environmentally derived infections are included, along with a view of the developing brain and host defence mechanisms. A review of experimental bacterial meningitis is provided, together with a discussion of its relevance for clinical and laboratory diagnosis, and for antimicrobial and supportive management. Prospects for the future in terms of early diagnosis, management and prevention are also addressed. In its collation of material from such a wide range of literature sources, this is a vital reference for all clinicians with an interest in the problems of meningitis in early life.
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PREFACE page vii
activity American Journal amphotericin ampicillin antibody antigen antimicrobial Archives of Disease associated babies bacteraemia bacterial meningitis birth blood born brain caused cell cent cerebral cerebrospinal fluid changes clinical colonisation concentrations considered controlled counts cultures diagnosis Disease in Childhood drugs early effective England Escherichia coli et al experimental factors figures findings five four gestational age given glucose gram-negative group B streptococcal Haemophilus influenzae human included increased infection Infectious Disease Journal initial intracranial pressure involved isolated Journal of Infectious Journal of Medicine Journal of Pediatrics later less levels maternal McCracken mean Medical months mortality Mycoplasma neonatal meningitis neonatal period newborn infants normal occurred organisms Pediatric Infectious Disease placenta positive possible pregnancy present protein range recorded reported response serum showed suggested term tests therapy treatment trial unit Ureaplasma Ureaplasma urealyticum viral virus weeks women