Principles of Medical Pharmacology

absorbed acetylcholine acid activity acute administration adrenaline adrenoceptors adverse agents agonists alcohol anaesthesia anaesthetic analgesic antagonists antibiotic atropine bacteria barbiturates benzodiazepines Bioavailability biotransformation block blockers blood pressure brain calcium carcinogens cardiac catecholamines cause cell CENTRAL NERVOUS CH₂ Chapter chemical chronic cimetidine clearance clinical compounds decrease depends diazepam digoxin disease diuretics dopamine dosage enzyme ethanol example excreted factors Figure fluid function gastric gastrointestinal half-life hepatic histamine hormone hypertension increased inhibition inhibitors injection insulin intestinal intravenous kidney L/kg levels liver MECHANISM OF ACTION membrane metabolism metabolites molecule morphine nerve nervous system neuroleptics neurons noradrenaline normal occur oral oxidation pathways patients penicillin peripheral Pharmacokinetics pharmacological phenobarbital phenytoin Plasma Protein Binding potential produce propranolol prostaglandin reactions receptors reduced release renal respiratory response result salicylate secretion serum side effects sodium specific stimulation Structural formulae sulfonamides synthesis Table teratogenic therapy tion tissue toxicity treatment tubular urine vascular vitamin µg/mL