Principles of Medical Pharmacology

absorbed absorption acid action activity acute addition administration adverse agents alcohol amount amphotericin anaesthetic animals antagonists appears associated binding block blood body brain calcium cause cell central changes Chapter chemical chronic clinical complex compounds concentration decrease depends depression disease distribution dose drug effects elimination enzyme example excreted factors Figure function given glucose half-life heart hepatic hormone human important increased indicates induced inhibition injection interaction intestinal intravenous lead less levels liver major means measured mechanism membrane metabolism metabolites muscle nerve noradrenaline normal occur oral organ patients Pharmacokinetics placenta plasma potential pressure prevent produce protein reactions receptors reduced relatively release renal response result secretion serum shown side effects similar sodium SPECIAL specific stimulation Structural studies synthesis Table therapeutic therapy tion tissue toxicity treatment urine usually various vitamin