Pancreatic CancerAndrew M. Lowy, Steven D. Leach, Philip Philip Springer Science & Business Media, 10 jul 2008 - 744 páginas Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. We have seen the development of the first mouse models that accurately recapitulate features of the human disease. Several landmark clinical trials in both resectable and metastatic pancreatic cancer have been completed, raising new questions about the standard of care in this disease. Finally, the era of targeted biologic therapies has engendered new excitement about the prospects of more rapid progress in understanding and successfully treating this dreadful disease. Therefore, it is an appropriate time to review these important advances and outline areas of controversy and question in pancreatic cancer biology and treatment. |
Índice
| 3 | |
| 27 | |
| 41 | |
Familial Pancreatic Cancer | 65 |
Hereditary Pancreatitis and Pancreatic Cancer | 81 |
Pancreatic Progenitor Cells in Injury and Regeneration Solomon Afelik and Jan Jensen 99 | 98 |
Development of the Endocrine and Exocrine | 117 |
Understanding | 137 |
Surgical Management of IPMN | 419 |
Drug Therapy Jane Pruemer and Michelle Rockey 435 | 434 |
Cachexia Anorexia Syndrome | 449 |
Endoscopic Palliation | 463 |
State of the Art in Radiation Therapy for Pancreas Cancer Aaron C Spalding and Edgar BenJosef 481 | 480 |
The Evolution of Chemoradiation Strategies for Locally | 497 |
Optimum Cytotoxic Therapy for Advanced Pancreatic Cancer | 511 |
Past | 535 |
Modeling Pathways | 159 |
Molecular Signaling Pathways in Pancreatic Cancer 181 | 180 |
Pancreatic Cancer Genomics Epigenomics | 229 |
Imaging of Pancreatic Adenocarcinoma | 255 |
The Role of PET Scanning in Pancreatic Cancer M FernandezUlloa | 271 |
Endoscopic Ultrasound Staging 285 | 284 |
Past and Present | 313 |
Total Pancreatectomy for Treatment of Pancreatic | 328 |
Vascular Resection for Pancreatic Cancer Waddah B AlRefaie and Jeffrey E Lee | 351 |
Complications of Pancreaticoduodenectomy 365 | 364 |
Controversies in the Surgical Management | 385 |
Laparoscopic Pancreatic Resections | 401 |
Neoadjuvant Treatment for Resectable and Locally | 548 |
An Overview of Clinical Trials of Targeted Therapies | 565 |
Utility of Animal Models in Pancreatic | 576 |
Kras Inhibitors and Pancreatic Cancer | 601 |
HER Family of Receptors as Treatment Targets | 608 |
GSK3β Inhibition in Pancreatic Cancer | 635 |
Novel Targets for the Treatment of Pancreatic Cancer | 665 |
Development of Vaccine Therapy for Pancreas Cancer Dung Le Elizabeth M Jaffee and Dan Laheru | 683 |
Novel Approaches in Chemoradiation for Localized | 705 |
Pitfalls in Clinical Trials and Future Directions Philip A Philip Lance K Heilbrun and Judith Abrams | 723 |
Otras ediciones - Ver todo
Pancreatic Cancer Andrew M. Lowy,Steven D. Leach,Philip Philip No hay ninguna vista previa disponible - 2008 |
Pancreatic Cancer Andrew M Lowy,Steven D Leach,Philip A Philip No hay ninguna vista previa disponible - 2016 |
Términos y frases comunes
acinar cells activation adenocarcinoma adjuvant advanced pancreatic cancer agents Ann Surg apoptosis bevacizumab biliary Biol cancer patients cell lines cetuximab chemoradiation chemotherapy chronic pancreatitis Clin Cancer Res Clin Oncol clinical trials combination cystic diagnosis differentiation disease distal pancreatectomy dose duct EGFR endocrine endoscopic epidermal growth factor epithelial erlotinib evaluation exocrine gemcitabine genetic growth factor receptor Hedgehog imaging increased inhibition inhibitors intraductal invasive IPMN K-ras kinase laparoscopic lesions malignant median survival metastasis metastatic mg/m² mice models molecular mouse mucinous mutations neoplasia neoplasms Notch Notch signaling Oncogene overexpression pancre pancreatic adenocarcinoma pancreatic cancer pancreatic cancer cells pancreatic carcinoma pancreatic ductal pancreatic tumors pancreaticoduodenectomy PanIN Pathol patients with advanced patients with locally patients with pancreatic phase II trial potential preoperative protein radiation therapy randomized resection response risk role signaling pathway Smad4 staging stent surgery surgical target tion tissue total pancreatectomy toxicity treatment unresectable versus
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