Pancreatic Cancer

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Andrew M. Lowy, Steven D. Leach, Philip Philip
Springer Science & Business Media, 10 jul 2008 - 744 páginas
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Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. We have seen the development of the first mouse models that accurately recapitulate features of the human disease. Several landmark clinical trials in both resectable and metastatic pancreatic cancer have been completed, raising new questions about the standard of care in this disease. Finally, the era of targeted biologic therapies has engendered new excitement about the prospects of more rapid progress in understanding and successfully treating this dreadful disease. Therefore, it is an appropriate time to review these important advances and outline areas of controversy and question in pancreatic cancer biology and treatment.

 

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Spectrum of Human Pancreatic Neoplasia
3
Molecular Genetics of Pancreatic Cancer
27
Pancreatic Intraepithelial Neoplasia
41
Familial Pancreatic Cancer
65
Hereditary Pancreatitis and Pancreatic Cancer
81
Pancreatic Progenitor Cells in Injury and Regeneration 99
98
Development of the Endocrine and Exocrine
117
Understanding
137
Surgical Management of IPMN
419
Drug Therapy 435
434
Cachexia Anorexia Syndrome
449
Endoscopic Palliation
463
State of the Art in Radiation Therapy for Pancreas Cancer 481
480
The Evolution of Chemoradiation Strategies for Locally
497
Optimum Cytotoxic Therapy for Advanced Pancreatic Cancer
511
Past
535

Modeling Pathways
159
Molecular Signaling Pathways in Pancreatic Cancer 181
180
Pancreatic Cancer Genomics Epigenomics
229
Imaging of Pancreatic Adenocarcinoma
255
The Role of PET Scanning in Pancreatic Cancer
271
Endoscopic Ultrasound Staging 285
284
Past and Present
313
Total Pancreatectomy for Treatment of Pancreatic
328
Vascular Resection for Pancreatic Cancer
351
Complications of Pancreaticoduodenectomy 365
364
Controversies in the Surgical Management
385
Laparoscopic Pancreatic Resections
401
Neoadjuvant Treatment for Resectable and Locally
548
An Overview of Clinical Trials of Targeted Therapies
565
Utility of Animal Models in Pancreatic
576
Kras Inhibitors and Pancreatic Cancer
601
HER Family of Receptors as Treatment Targets
608
GSK3β Inhibition in Pancreatic Cancer
635
Novel Targets for the Treatment of Pancreatic Cancer
665
Development of Vaccine Therapy for Pancreas Cancer
683
Novel Approaches in Chemoradiation for Localized
705
Pitfalls in Clinical Trials and Future Directions
723
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