Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

Portada
CRC Press, 6 oct 1997 - 576 páginas
Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.
 

Índice

The Importance of OxidantAntioxidant Balance
3
The Effect of Oxidative Stress on Cells by Oxygen Radicals and Its Inhibition by Antioxidants
11
Cytotoxicity of RadiationDerived Reactive Oxygen Species
17
Regulation of the Bacterial Response to Hydrogen Peroxide
31
Activation of Lymphocyte Signal Pathways by Oxidative Stress Role of Tyrosine Kinases and Phosphatases
37
Oxidantmediated Modulation of Phospholipases in Endothelial Cells Possible Implication in Vascular Disorders
47
NFkB Transcription Factor Activation Importance of the Redox Regulation
65
Redox Regulation of the NFkB Signaling Pathway and Disease Control
77
Flavonoid Functions In Vivo Are They Predominantly Antioxidants?
287
Immunoregulatory Properties of Superoxide Dismutase
307
Pharmacological Inhibition of Endothelial Cytoskeleton Alterations Induced by Hydrogen Peroxide and TNF𝛼
315
Perinatal Development of Superoxide Dismutase and Other Antioxidant Enzyme Activities in Ratbrain Mitochondria
325
Coexistence of a Reactive Oxygen Cycle with QCycle and H+Cycle in the Respiratory Chain A Hypothesis for the Generation Partitioning Targeting a...
335
Endogenous Oxidative DNA Damage and Spontaneous Mutagenesis Role of 8Oxoguanine
353
The Elevated Serum Level of Thioredoxin in Patients with Malignant Disease and Chronic Inflammatory Diseases
361
The Role of Free Radicals in Antitumor Effects of Cancer Treatments
371

Mechanism of Activation of NFkB by Hydrogen Peroxide
85
Selfregulation of the NFkBlkB𝛼 System and Its Positive and Negative Control by the Cellular Redox Status
91
The Role of Hydrogen Peroxide in Signal Transduction and the Involvement of Iron
99
Redox Regulation of Heat Shock Protein Expression and Protective Effects Against Oxidative Stress
115
LowDensity Lipoproteins Modulate Nitric Oxide and Heme Oxygenase Signal Transduction Pathways in Vascular Endothelium and Smooth Muscle
129
Nitric Oxidestimulated Tyrosine Phosphorylationdependent Signaling Pathways in Cultured Cells
141
Regulation of Cell Activation by Receptors for IgG
149
Signal Transduction Pathways Activated by Mitogenic Neuropeptides
165
Glutathione Metabolism During Apoptosis
181
Endogenously Generated Superoxide and Hydrogen Peroxide in the Redox Modulation of Cell Proliferation Apoptosis and Virus Replication
193
DeoxyDRiboselnduced GSH Depletion and Induction of Apoptosis in Human Quiescent Peripheral Blood Mononuclear Cells Effects of NAcetylcyste...
201
Nitric Oxide and Hydrogen Peroxide Production during Apoptosis of Human Neutrophils
207
The Mitochondrion as a SensorEffector of Oxidative Stress During Apoptosis
215
Antioxidants and the Regulation of Reactive Iron
225
Redox Regulation by the Thioredoxin and Glutaredoxin Systems
231
ThioredoxinAdult T Cell LeukemiaDerived Factor as the Key Redox Regulator of Signaling
249
Therapeutic Potential of the Antioxidant and Redox Properties of 𝛼Lipoic Acid
253
Glutathione Compartmentation and Oxidative Stress
271
The Role of Cysteine and Glutathione in the Pathogenesis of HIV Infection Effects of Treatment with NAcetylcysteine
375
Low Glutathione Levels in CD4 T Cells Predict Poor Survival in AIDS NAcetylcysteine May Improve Survival
381
Modulation of HIV1 Long Terminal Repeat by Arachidonic Acid
391
Protein Degradation in Lymphocytes as an Indicator of Oxidative Stress in HIV Infection
401
Oxidative Stress and AIDS Oneyear Supplementation of HIVpositive Patients with Selenium or 𝛃Carotene
411
Glutathione Oxidation and Mitochondrial DNA Damage in AIDS Effect of Zidovudine
431
Effect of LCarnitine Treatment In Vivo on Apoptosis and Ceramide Generation by Peripheral Blood Lymphocytes from AIDS Patients
439
Nutriceutical Modulation of Glutathione with a Humanized Native Milk Serum Protein Isolate IMMUNOCAL Application in AIDS and Cancer
449
Successful Antioxidant Therapy Including Superoxide Dismutase Associated with Antiretroviral Therapy in an HIVInfected Patient with Hepatitis Bre...
465
Parkinsons Disease Apoptosis and Oxidative Stress
471
Protein Oxidation and Glycation in Neurodegenerative Diseases
487
Glycation as Oxidative Stress and Redox Regulation Implications for Aging Diabetes and Familial Amyotrophic Lateral Sclerosis
499
Oxidative Stress in IschemiaReperfusion Reillys Irritation Syndrome Revisited
505
Evaluation of the Antiperoxidase Defense System of the Lens Utilizing GSH Peroxidase Transgenics and Knockouts
509
The Rheumatoid Joint RedoxParadox?
519
Chronic Oxidative Stress in Rheumatoid Arthritis Implications for T Cell Function
539
Index
549
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