Networks in Cell Biology

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Mark Buchanan
Cambridge University Press, 13 may. 2010 - 271 páginas
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The science of complex biological networks is transforming research in areas ranging from evolutionary biology to medicine. This is the first book on the subject, providing a comprehensive introduction to complex network science and its biological applications. With contributions from key leaders in both network theory and modern cell biology, this book discusses the network science that is increasingly foundational for systems biology and the quantitative understanding of living systems. It surveys studies in the quantitative structure and dynamics of genetic regulatory networks, molecular networks underlying cellular metabolism, and other fundamental biological processes. The book balances empirical studies and theory to give a unified overview of this interdisciplinary science. It is a key introductory text for graduate students and researchers in physics, biology and biochemistry, and presents ideas and techniques from fields outside the reader's own area of specialization.
 

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Índice

Introduction
1
1 Network views of the cell
4
2 Transcriptional regulatory networks
14
3 Transcription factors and gene regulatory networks
36
4 Experimental methods for protein interaction identification
53
5 Modeling protein interaction networks
83
6 Dynamics and evolution of metabolic networks
93
the case of metabolic networks
117
8 Signalling networks
135
from local to global properties
170
Appendix B Modelling the local structure of networks
188
Appendix C Higherorder topological properties
210
Appendix D Elementary mathematical concepts
219
References
235
Index
269
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Sobre el autor (2010)

Mark Buchanan is a physicist and independent author. He writes a monthly column for the journal Nature Physics.

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