Networks in Cell BiologyMark Buchanan, Guido Caldarelli, Paolo De Los Rios, Francesco Rao, Michele Vendruscolo Cambridge University Press, 13 may 2010 - 271 páginas The science of complex biological networks is transforming research in areas ranging from evolutionary biology to medicine. This is the first book on the subject, providing a comprehensive introduction to complex network science and its biological applications. With contributions from key leaders in both network theory and modern cell biology, this book discusses the network science that is increasingly foundational for systems biology and the quantitative understanding of living systems. It surveys studies in the quantitative structure and dynamics of genetic regulatory networks, molecular networks underlying cellular metabolism, and other fundamental biological processes. The book balances empirical studies and theory to give a unified overview of this interdisciplinary science. It is a key introductory text for graduate students and researchers in physics, biology and biochemistry, and presents ideas and techniques from fields outside the reader's own area of specialization. |
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Índice
Introduction | 1 |
1 Network views of the cell | 4 |
2 Transcriptional regulatory networks | 14 |
3 Transcription factors and gene regulatory networks | 36 |
4 Experimental methods for protein interaction identification | 53 |
5 Modeling protein interaction networks | 83 |
6 Dynamics and evolution of metabolic networks | 93 |
the case of metabolic networks | 117 |
8 Signalling networks | 135 |
from local to global properties | 170 |
Appendix B Modelling the local structure of networks | 188 |
Appendix C Higherorder topological properties | 210 |
Appendix D Elementary mathematical concepts | 219 |
References | 235 |
| 269 | |
Términos y frases comunes
Acids activation adjacency matrix affinity tags algorithm analysis approach average bait binding sites biochemical boolean Caldarelli caspase Cell Biology cellular cis-regulatory elements clustering coefficient components computed connected database defined definition degree distribution directed networks DNA-binding domain dynamics enzyme Escherichia coli eukaryotes evolution first flux function G protein gene expression genetic genome graph hierarchical identified interacting proteins interaction networks intracellular involving large number ligand mechanisms metabolic network metabolites methods modules Molecular Biology molecules multiple Nature Reviews NF-kB nodes organisms peptides phosphorylation prediction probability promoter properties protein complexes protein interaction protein kinase protein–protein interactions proteomics purification R-SMAD random reactions real networks receptor regulatory interactions response RG model role signal transduction signalling networks signalling pathways significant specific structure substrates subunit target genes tion topological transcription factors transcriptional networks transcriptional regulation transcriptional regulatory network tyrosine undirected variable vertex vertices yeast two-hybrid
Información bibliográfica
| Título | Networks in Cell Biology |
| Editores | Mark Buchanan, Guido Caldarelli, Paolo De Los Rios, Francesco Rao, Michele Vendruscolo |
| Edición | ilustrada |
| Editor | Cambridge University Press, 2010 |
| ISBN | 0521882737, 9780521882736 |
| N.º de páginas | 271 páginas |
| Exportar cita | BiBTeX EndNote RefMan |