EpigeneticsC. David Allis, Thomas Jenuwein, Danny Reinberg CSHL Press, 2007 - 502 páginas The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation. |
Índice
1 | |
15 | |
23 | |
Ch 4 Epigenetics in S cerevisiae | 63 |
Ch 5 PostEffect Variegation Heterochromatin Formation and Gene Silencing in Drosophila | 81 |
S pombe and N crassa | 101 |
Ch 7 Epigenetics of Ciliates | 127 |
Ch 8 RNAi and Heterochromatin Assembly | 151 |
Ch 16 Dosage Compensation in Drosophila | 307 |
Ch 17 Dosage Compensation in Mammals | 321 |
Ch 18 DNA Methylation in Mammals | 341 |
Ch 19 Genomic Imprinting in Mammals | 357 |
Ch 20 Germ Line and Pluripotent Stem Cells | 377 |
Ch 21 Epigenetic Control of Lymphopoiesis | 397 |
Ch 22 Nuclear Transplantation and the Reprogramming of the Genome | 415 |
Ch 23 Epigenetics and Human Disease | 435 |
Ch 9 Epigenetic Regulation in Plants | 167 |
Ch 10 Chromatin Modifications and Their Mechanisms of Action | 191 |
Ch 11 Transcriptional Silencing by Polycomb Group Proteins | 211 |
Ch 12 Transcriptional Regulation by Trithorax Group Proteins | 231 |
Ch 13 Histone Variants and Epigenetics | 249 |
Ch 14 Epigenetic Regulation of Chromosome Inheritance | 265 |
Ch 15 Epigenetic Regulation of X Chromosomes in C elegans | 291 |
Ch 24 Epigenetic Determinants of Cancer | 457 |
App 1 WWW Resources | 477 |
App 2 Histone Modification and References | 479 |
Index | 491 |
Back Cover End Page | 503 |
Back Cover | 504 |
Otras ediciones - Ver todo
Epigenetics C. David Allis,Thomas Jenuwein,Danny Reinberg No hay ninguna vista previa disponible - 2007 |
Epigenetics C. David Allis,Marie-Laure Caparros,Thomas Jenuwein,Danny Reinberg No hay ninguna vista previa disponible - 2015 |
Términos y frases comunes
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